Elien Alderweireldt

Postdoc

Ghent University

Human health effects Nanoplastic method development

Research Focus

My research focuses on understanding how micro- and nanoplastics (MNPs) may affect human health, with a particular emphasis on liver-related outcomes and cellular metabolism. Using advanced in vitro models, I investigate how these particles interact with biological systems and influence cellular function at physiologically relevant exposure levels. A central aspect of my work is the development and optimization of in vitro models that can better capture the complexity of human exposure and tissue responses. I apply bioenergetic approaches, using for example Seahorse XF analysis and IncuCyte Live Cell Analysis, to evaluate how MNP exposure alters cellular energy production, oxidative metabolism, and stress responses. By studying changes in pathways such as oxidative phosphorylation and glycolysis, my research aims to identify early mechanistic events that may contribute to adverse health effects. Through this work, I aim to support more mechanistically informed risk assessment strategies for MNPs and contribute to the development of reliable experimental platforms for studying emerging environmental contaminants and their impact on human health.